Core Nutritionals : Core FLEX
Intense weight training can give joints, cartilage, and other connective tissue a pounding. More dangerously, ongoing joint pain can be a symptom of systemic or chronic inflammation. Chronic inflammation is a breakdown in the bodyâs self-healing mechanisms in response to stress, inadequate sleep, and poor nutrition. Many doctors cite systemic inflammation as a leading cause of âmetabolic syndromeââthe complex of degenerative diseases that includes atherosclerosis, obesity, arthritis, diabetes, hypertension, and cancer.
No supplement can cure stress or overcome a terrible diet. But when combined with exercise and a healthy lifestyle, Core FLEX offers a potent combination of ingredients to help directly repair tissue damage in and around the joints, reduce chronic inflammation to restore a balanced metabolic state, and prevent future repetitive stress injuries.*
Non steroidal anti-inflammatory drugs (NSAIDs), such as aspirin and ibuprofen, can help reduce pain and inflammation but are not a long term solution. They can inhibit muscle building protein synthesis and have other negative side effects. Core FLEX provides a superior alternative that will counteract joint pain and inflammation without undermining your hard work in the gym.*
You canât drive a race car on broken axles. And you canât build an impressive physique, or achieve optimal athletic performance, with weak and painful joints. Core FLEX is the perfect, all-in-one joint health product that scientifically combines significant doses of 11 powerful ingredients, backed by clinical research, to build healthy joints and combat the damaging effects of chronic inflammation.*
Each serving of Core FLEX contains:
- Chondroitin sulfate 800mg
- Glucosamine sulfate 1400mg
- MSM (methylsulfonylmethane) 1000mg
- Cissus quadrangularis (10% ketosterones) 800mg
- Black cherry extract (Prunus cerasus, 5:1) 100mg
- Turmeric (95% curcumin) 500mg
- Boswellia (37% boswellic acids) 800mg
- Bromelain (2400 GDU/g) 400mg
- Vitamin C (ascorbic acid) 500mg
- Vitamin D3 (cholecalciferol) 1000IU
- Black pepper extract (95% piperine) 5mg
Physiological Properties and Effects
Chondroitin and Glucosamine are substances found naturally in the body. Glucosamine is a form of amino sugar that is a precursor to a molecule called a glycosaminoglycan, which is used in the formation and repair of cartilage. It also aids in lubricating and providing thickness to the cartilage around damaged joints. Chondroitin sulfate is a type of glycosaminoglycan rich in sulfur and is a relative of glucosamine. It is one of the major constituents of cartilage and helps provide structure. It also assists in lubricating joints by helping retain water in cartilage, and may help stimulate the formation of new tissue. Studies have shown that patients supplementing with glucosamine andchondroitin for one to two months experience pain relief similar to that achieved though NSAIDS, without the side effects.*
Methylsulfonylmethane (MSM) is a naturally occurring, organic, sulfur-containing compound. MSM appears to inhibit pain impulses that travel along nerve fibers, acting as an analgesic. Because of this property and MSMâs potential anti-inflammatory actions, MSM is often used for combating the symptoms of arthritis, chronic back pain, and carpal tunnel syndrome. Studies have shown that sulfur levels in arthritic joints are lower than in healthy joints, and MSM may help by delivering needed sulfur to the afflicted areas. It may also help to maintain or repair cartilage and reduce the formation of scar tissue, which can inhibit full range of muscular motion.*
Cissus quadrangularis is a unique blend of vitamins, minerals, and plant sterol compounds thatcan facilitate the building and strengthening of muscle and bone, help deliver nutrients to tendon related injuries, and soothe the pain of sports related injuries. Studies have shown that cissus has the ability to speed bone fracture healing and can lead to a much faster increase in bone tensile strength. Most research on cissus focuses on its bone healing properties; however, cissus may improve the healing rate of connective tissue in general, including tendons. Cissus also has analgesic and anti-catabolic effects.*
Black cherry extract contains a number of beneficial compounds, including high levels of anthocyanin, which has been found to reduce joint pain and inflammation. It is rich in antioxidant and anti-carcinogenic agents such as phenolic compounds, catechins, chlorogenic acid, and flavonal glycoside, and has been used to treat gout, by lowering urate levels, as well as arthritis. A study on obese rodents found that tart cherry consumption reduced several phenotypes of metabolic syndrome and reduced both systemic and local inflammation. Black cherry extract also contains melatonin, which contributes to regular circadian rhythms and restful sleep.*
Turmeric (95% curcumin) is a root that in numerous studies seems to powerfully inhibit the enzymes that synthesize inflammatory compounds such as prostaglandins and leukotrienes. The high curcumin extraction in Core FLEX (95%) means the active ingredients, curcuminoids, can achieve their full antioxidant and anti-inflammatory potential. A laboratory study of the curcuminoids suggests they compare favorably to aspirin and non-steroidal anti-inflammatories in effectiveness, but without some negative side-effects on blood clotting (making it a preferable anti-arthritic therapy especially for anyone who may be prone to vascular thrombosis). One double-blind study on arthritis patients found that curcumin provided significant improvements for all the subjects.*
Boswellia (37.5% boswellic acids) is a tree resin extract that is a traditional part of Indianmedicine. In modern clinical trials the active agency, boswellic acid, has been found to reduce joint pain and arthritis by inhibiting production of inflammatory leukotrienes. Treatment with boswellia appears to increase flexion of the joints, aid in lubricating and cushioning joint movements, and in one study facilitated increased walking distances in patients with arthritis of the knee. Additional studies found boswellia to be effective for alleviating colitis and asthma.*
Bromelain (2400GDU/g) is a collection of protein-digesting enzymes found in pineapple juice and in the stem of pineapple plants. It has been shown to have a myriad of health benefits including wound healing enhancement, anti-tumor actions, and improving cardiovascular and circulatory function. The mechanism of the anti-inflammatory activity is not very well understood, but like curcumin and boswellia it appears to control the proliferation of prostaglandins. Numerous studies have shown bromelainâs ability to speed healing time and reduce pain following various surgical procedures.*
Vitamin C is not only a powerful antioxidant, but also strengthens the immune system, protectscells from oxidized particles and free radicals, and assists other physiological functions. A major study by the University of California at Berkeley found that supplementing with 500 milligrams of Vitamin C (the daily dose contained in Core FLEX) led to a 24% reduction in levels of C-reactive protein, a consistent marker of inflammation. In conjunction with the other ingredients, it is important component of strong joints and overall health.*
Vitamin D3 is an essential hormone precursor that plays a vital role in many metabolic functions,including bone health, blood glucose levels and insulin resistance, immune system support, blood pressure regulation, muscle protein synthesis, and body fat control. Clinical trials have even linked Vitamin D3 with decreased risk of cancer. Although some foods contain Vitamin D3, the human body generates most of its Vitamin D3 needs from the skin through regular exposure to sunlight. Severe Vitamin D3 deficiency is a significant and widespread problem, especially in North America. Vitamin D3 may be the most important single supplement individuals can add to their daily diet to improve overall health; itâs well-known properties for strengthening bones and controlling inflammation make it an especially valuable ingredient in Core FLEX.*
Piperine (95%), a black pepper extract, is included because it dramatically increases thebioavailability of curcuminoids (see above). Without piperine, the serum concentration andabsorption rates of the active agents in curcumin would be significantly reduced. Piperine facilities the full antioxidant and anti-inflammatory effects of the curcumin.*
- Ammon HP, et al. Pharmacology of Curcuma longa. Planta Med. Feb1991;57(1):1-7.
- Block G, Jensen C, Dietrich M, Norkus EP, Hudes M, Packer L, Plasma C-reactive protein concentrations in active and passive smokers: influenceof antioxidant supplementation. J Am Coll Nutr. 2004 Apr;23(2):141-7.
- Braham R, Dawson B, Goodman C. The effect of glucosamine supplementation on people experiencing regular knee pain. Br J Sports Med.2003;37(1):45-9.
- Brien S, Lewith G, Walker A. Hicks SM. Middleton D. Bromelain as a Treatment for Osteoarthritis a Review of Clinical Studies. Evidence-basedComplementary and Alternative Medicine. 2004;1(3)251-257.
- Carlberg C, Dunlop TW. The impact of chromatin organization of vitamin D target genes. Anticancer Res. 2006 Jul-Aug;26(4A):2637-45.
- Chopra SS, Patel MR, Awadhiya RP. Studies of Cissus quadrangularis in experimental fracture repair: a histopathological study Indian J Med Res.1976 Sep;64(9):1365-8.
- Chopra SS, Patel MR, Gupta LP, Datta IC. Studies on Cissus quadrangularis in experimental fracture repair: effect on chemical parameters in bloodIndian J Med Res. 1975 Jun;63(6):824-8.
- Cranney A, Weiler HA, OâDonnell S, Puil L. Summary of evidence-based review on vitamin D efficacy and safety in relation to bone health. Am JClin Nutr. 2008 Aug;88(2):513S-519S.
- D. S. Kelley, R. Rasooly, R. A. Jacob, A. A. Kader, and B. E. Mackey, Consumption of Bing Sweet Cherries Lowers Circulating Concentrations ofInflammation Markers in Healthy Men and Women. J. Nutr., April 1, 2006; 136(4): 981 â 986.
- du Souich P, GarcÃa AG, VergÃ©s J, Montell E. Immunomodulatory and anti-inflammatory effects of chondroitin sulphate. J Cell Mol Med. 2009Aug;13(8A):1451-63. Epub 2009 Jun 11.
- Gaspani L, Lim roll E, Ferrario P, Bianchi M. In vivo and in vitro effects of bromelain on PGE(2) and SP concentrations in the inflammatoryexudate in rats. Pharmacology 2002;65(2):83-6.
- 240 Capsules
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